The purpose of research was to develop software for the hardware and software complex of low-frequency piezothromboelastography "NPTEG Mednord", designed for bedside assessment of the functional state of the hemostasis system using the patient's native blood (whole blood studies in Point-of-care test mode).

Methods. The software development of the complex consisted of software for the microcontroller of the device and user software. The article presents the results of the development of algorithms for data processing and software development for the hardware and software complex of low-frequency piezothromboelastography "NPTEG Mednord". The main software solutions for collecting and processing data from a piezoelectric sensor that registers changes in the aggregate state of native venous blood are considered.

Results. An example of a control command designed to link the hardware and software parts of the complex is given. The main attention in the article is paid to the software for a personal computer that controls the hardware, processes primary data, displays the curve of the blood clotting process in real time (changes in the viscosity of the clot over time), obtaining reference points, and selecting design parameters. The interface of the developed application is presented, indicating the main tabs necessary for the work of doctors. Vascular-platelet hemostasis was assessed in conditionally healthy volunteers of the Siberian population in real time using a piezothromboelastograph "NPTEG Mednord" with the developed software. A correlation analysis of the selected parameters of a low-frequency piezothromboelastogram with existing methods of studying the hemostasis system was performed.

Conclusion. The developed software "Gemo-5" is designed to work as part of the hardware and software complex "NPTEG Mednord", registered as a medical device (No. RZN 2020/12855). The software of the complex includes: microcontroller software, user part, DBMS. The software of the hardware and software complex allows you to evaluate 21 parameters of the hemostasis system, including continuous monitoring of the state of the hemostasis system (on-line).

The purpose of research is to develop a microwave device-a new ultra-low intensity radiation in the range of 1 GHz and a power of <10 MW, designed for conducting biomedical experimental studies.

Methods. The scientific work was carried out by a translational group of researchers, including doctors, biologists, engineers, radiophysicists and programmers. In the materials of the article, the structure of the microwave generation module of the device, the structure and the circuit diagram of the timer of the device are considered. The reasons for the choice of biomodulation frequencies are given on the basis of the fundamental principles of chronobiology, taking into account the cyclic processes of cell functioning, namely, the elongation of the protein synthesis chain, microcirculation rhythms, the work of the thermoregulation center, near-hourly cycles of cell division and RNA synthesis.

Results. Based on the conducted research, the structure of a low-frequency biomodulator has been developed and presented. The functioning of the device is provided by the developed program code of the microcontroller. The developed mock-up sample of the device was tested using the spectrum and signal analyzer of the German company: ROHDE & SCHVARZ FSV SIGNAL ANALYZER 5 kHz 40 GHz. The sig-nal taken from the frame antenna of the device had a frequency of 1000 MHz with a signal quality of 100 kHz.

Conclusions. The positive effect of the effect of ultra-low intensity microwave radiation on mesenchymal stem cells (MSCs) is shown. A significant increase in the intensity of MSCS fluorescence in the mode of low-frequency biomodulation was revealed.

The purpose of research development of a method for parametric synthesis of systems for providing electromagnetic access by means of radio monitoring of radio emission sources with quadrature amplitude modulation of various positioning of satellite communication systems.

Methods. Probability theory, mathematical statistics, statistical radio engineering and computational mathematics were used in conducting research and developing a method for synthesizing an electromagnetic access system. Signal constellations with quadrature amplitude modulation with positivity L no more than 256 and nonuniformity X = 1 are considered as accepted assumptions. This decision is justified by their use in modern and promising satellite radio systems for information transmission. In the paper, all the results of the probability of reliability of the received data by means of radio monitoring are reflected for the case of rigid decision-making.

Results. Mathematical models of the dependence of equivalent energy losses in structural and functional nodes on destabilizing factors have been developed for a given probability of reliability of receiving signals with quadrature amplitude modulation on the symbol; an integral assessment of the quality of radio monitoring of fixed and mobile satellite communication lines has been determined; the cost of creating such radio engineering paths as antenna-feeder on domestic and foreign bases has been estimated., receiving-selecting, demodulating; A procedure has been developed for parametric synthesis of systems for providing electromagnetic access of radio monitoring facilities to the resources of satellite communication lines, taking into account the efficiency indicators of providing electromagnetic access.

Conclusion. The scientific work presents a method of parametric synthesis of systems for providing electromagnetic access to radio monitoring means of digital satellite communication lines with complex types of modulation, which differs from the known ones by taking into account energy losses in structural and functional units previously neglected due to their low influence associated with low data exchange rates.

The purpose of research. Timely detection of the fire source at the stage of its development allows to reduce both material and human losses. Therefore, the purpose of the research was to develop models, methods and algorithms for controlling the fire and medical and environmental safety monitoring system, ensuring an increase in its effectiveness through the analysis of video data from unmanned aerial vehicles.

Methods. The method of classifying aerial photographs of a video sequence when monitoring a fire situation involves their decomposition into rectangular segments of a given size and assigning them to one of three classes: smoke, flame, indifferent class. "Strong" and "weak" classifiers are used to classify segments. The Walsh-Hadamard transform was used to generate descriptors for "weak" classifiers. Descriptors are calculated for three "weak" classifiers. First, the Walsh-Hadamard transform is calculated for the window of the entire segment and its spectral coefficients are used for the first "weak" classifier. Then descriptors are calculated for two windows whose sizes are two and four times smaller than the size of the original window.

Results. The classifier consists of three independently trained neural networks - "weak" classifiers. A simple ensemble averaging unit is used to combine the output data of neural networks. The software for classification of aerial photographs has been developed, which allows to form a database of segments of the "smoke" and "flame" classes, to determine the two-dimensional Walsh-Hadamard spectrum of aerial photograph segments, to train fully connected neural networks and to conduct research analysis to study the relevance of two-dimensional spectral coefficients.

Conclusion. Experimental studies on the classification of video data containing flame and smoke showed an average smoke detection accuracy of 86%, and flame detection of 89,5%. Type II errors averaged 13% for smoke detection and 4,5% for flame detection. To set up and check the classifiers, we used real data from surveillance cameras in open spaces.

The purpose of research is to study and substantiate the targeted use of components, usually products of natural origin, which, when used, had a certain therapeutic and preventive effect on given systems or functions of the human body.

Methods. The objects of the study were: vegetable raw materials of St. John's wort herb (Hyperici herba), medicinal sage leaves (Tinctura Salviae), inflorescences of marigolds prostrate (Tagetes patula L), cherry fruit flour, gluten-free raw materials - lupine flour "Lupisan". Sampling and preparation of samples for laboratory studies was carried out according to the unified methodology for studying domestic food products, finished products - according to GOST 5904. To extract biologically active substances from the leaves of medicinal sage, St. John's wort and marigolds prostrate, extraction options were used: maceration method; percolation method; fractional maceration method.

Results. It was found that the amount of extractives in St. John's wort tinctures obtained by maceration was almost the same at both concentrations, and in the case of sage and marigold tinctures, the amount of extractives in tinctures with 70% alcohol increased 1,6 times. The results of the studies of the extraction options under study showed that the most effective extraction method is the fractional maceration method, where the amount of extractive substances in tinctures is the largest, and ethanol concentrations of 40% and 70% do not play a special role in their yield and can be interchangeable.

Conclusion. A scheme for the production of tinctures by fractional maceration is proposed, conditions for chromatographic determination of rutin and spectrophotometric determination of the amount of flavonoids are selected. The use of enriching additives containing non-traditional vegetable raw materials (lupine flour, cherry fruit flour, sage extract and marigold extract) is justified in order to increase the nutritional and biological value of finished products that provide the necessary therapeutic and preventive orientation. Formulations and technology for the production of functional food products (bread and bakery products) containing enriching additives have been developed.

The purpose of research. The analysis of the fire hazard of forest fires, the analysis of fire safety requirements aimed at limiting the consequences of the spread of fire between forest stands and various buildings, structures showed that to assess the value of the fire-fighting distance, it is necessary to take into account the method of flammability of fire- hazardous irradiated material from the effects of radiating heat flow from a forest fire (riding, grassroots). In order to increase the effectiveness of the use of modern methods for predicting a fire-hazardous situation and to develop basic recommendations for improving the set of measures aimed at preventing forest fires and mitigating their consequences, it is necessary to develop a method and algorithm for its practical implementation.

Methods. To determine the minimum permissible value of the fire-fighting distance from forest stands to various buildings, structures (objects of protection), a method has been developed that allows assessing the threat of the risk of harm to objects of protection during the burning of forest stands (grassroots and riding fires) based on the use of various methods for establishing fire danger from forest fire.Gorenje And for its practical application, an algorithm for estimating the fire-fighting distance from forest stands (riding, grassroots) to various buildings and structures is proposed.

Results. The application of the method and algorithm will allow for modeling scenarios of the occurrence of dangerous natural processes and fire phenomena in forests located near urban settlements and establish a safe distance between them.

Conclusion. The proposed information and analytical assessment of the danger of forest fires is aimed at increasing the level of protection of settlements from forest fires in the exercise of the powers of state authorities of the Russian Federation in the field of forest relations and the powers of supervisory authorities of the Ministry of Emergency Situations of Russia.

Purpose of research. Development of proposals for the implementation of cryptographic protection of channels for organizing communication using the MA VLink protocol when controlling autonomous unmanned aerial vehicles.

Methods. When conducting research and developing a method for implementing channel protection for the organization of communication via the MA VLink protocol when controlling autonomous unmanned aerial vehicles, multicriteria analysis methods were used. The initial firmware check is performed when the autopilot is loaded/initialized. In this case, methods are used to check the contents of the autopilot memory, such as using a hashing chain with a random request, which may require a static hash for comparison. To counteract the threats of the functional flight control module, it is recommended to use IDS (Intrusion detection systems). IDS is usually software and hardware that checks the system for anomalies and deviations.

Results. A method for implementing cryptographic channel protection for the organization of communication via the MA VLink protocol when controlling autonomous unmanned aerial vehicles based on the ChaCha20 encryption algorithm is proposed. The analysis and synthesis of methods for ensuring the security of control channels and data transmission between the NPU and autonomous unmanned aerial vehicles has been carried out. The analysis of the AES- CTR, AES-CBC, ChaCha20 and RC4 encryption protocols was performed, the results of which made it possible to establish ChaCha20 as the most suitable method of cryptographic protection of UA Vs running MA VLink. The results of experiments conducted to test the ChaCha20 encryption algorithm showed that the use of this algorithm does not affect the performance of the MAVLink protocol, since it uses the same processor time.

Conclusion. The analysis of methods of cryptographic protection of channels for the organization of communication using the MAVLink protocol when controlling autonomous unmanned aerial vehicles is carried out, on the basis of which a method for implementing channel protection using the MA VLink protocol when controlling UA Vs based on the ChaCha20 encryption algorithm is proposed.

The purpose of research is to develop and automate the process of finding fellow travelers for long-distance car trips. The relevance of the development is determined by the need to create domestic software as part of the replacement of software developed by companies that have suspended or ceased their activities in the territory of the Russian Federation, digitalization of the region, as well as in connection with the implementation of the project"Digital Economy of the Russian Federation", the proposed software increases the availability of intercity traffic while improving driver safety and passengers. In order to simplify the process of moving passengers between localities, and to optimize time and costs, an online service model for organizing long-distance trips is proposed. Public transport is not always a suitable option, and therefore the time costs increase to reach the desired point, while the cost of gasoline when traveling by private transport is often more expensive than by public transport, albeit with a large com-fort.

Methods. The development of the web application was carried out with the help of ASP.NET Core, the application interface was developed using ASP.NET Core MVC. The web application allows you to view data about existing scheduled trips and publish information about your trips.

Results. In the course of the work, an online travel search service for long-distance trips was developed and implemented. All the basic functions necessary to perform the main tasks of the web application have been successfully implemented, the connected database works stably.

Conclusion. The developed software product can be used in everyday life to search for vehicles.

The purpose of research is a comprehensive combination of models of mathematical prediction and initial diagnosis of neurotoxicosis in welding workers, providing, acceptable for preventive medicine, and in particular for occupational pathologists, the quality of decision-making.

Methods. In the image of the basic mathematical apparatus, the technology of soft computing and, in particular, the methodology of synthesis of hybrid fuzzy decision rules, widely used when solving problems with a similar data structure and type of fuzziness, taking into account the uncertainty of the description of the class of occupational diseases under study, is chosen. The synthesis method selected and adapted to the tasks being solved makes it possible to take into account the multiplicative effect of harmful chemicals on the human body, such as manganese, aluminum, copper, carbon monoxide and others generated by the welding process, taking into account exposure time and other significant endogenous and exogenous risk factors.

Results. The obtained models of mathematical forecasting and early diagnosis of neurotoxicosis in welding workers, in addition to the effects of aerosol, dust and fibrogenic risk factors on the human body, allow us to take into account unfavorable environmental factors of a different nature in combination with the peculiarities of individual risk factors and ergonomics of welding shops. During the final modeling and expert evaluation, it was presented that the resulting mathematical model provides confidence in the correct prognosis of the development and appearance of neurotoxicosis in welding workers at least 0,85, and early diagnosis at least 0,9.

Conclusion. Fuzzy models of mathematical forecasting and early diagnosis of neurotoxicosis in welding workers were obtained, where the primary causes of risk are industrial aerosols with a high content of chemicals, in combination with other endogenous and exogenous risk factors. It is presented that the confidence in the prognosis exceeds 0.85, and in the presence of early stages - 0,9, which allows us to recommend the results obtained in the practice of specialized occupational pathologists.

The purpose of research is to develop a model for describing and evaluating the effectiveness of solving the coefficient inverse problem of analyzing and processing information about an algebraic polynomial with given coefficients of terms of lower degrees under the influence of input data error on the solution efficiency.

Methods. As a basic mathematical apparatus, the methodology for solving inverse problems with the approximation of functions by the Lagrange interpolation polynomial is used. Under the conditions of a uniform continuous error rate of the input data, when evaluating the efficiency of solving the coefficient inverse problem, it is proposed to use the minimum value of the objective function in the form of the minimum of the Lebesgue function. When deriving explicit formulas for the optimal plan of coordinates of the nodes of the approximation grid, it is proposed to apply the alternance characteristic of the extremal polynomial.

Results. As the basic elements of a mathematical model for analyzing and processing information about an algebraic polynomial in solving a coefficient inverse problem, Lagrange interpolation polynomials were used with a numerical estimate of the solution efficiency by the value of the minimum of the Lebesgue function.

Conclusion. In the course of the research, we solved the problem of developing a model for describing and evaluating the efficiency of the coefficient inverse problem of analyzing and processing information about an algebraic polynomial with given coefficients of terms of lower degrees and with the influence of the input data error on the accuracy of the solution. It is shown that to quantify the effectiveness of solving the problem, one should use the value of the objective function in the form of the minimum of the Lebesgue function, and to calculate the coefficients of the approximate polynomial, use the Lagrange interpolation polynomial.