Use of Indicators Characterizing Adaptation Mechanisms to Assess the Level of Protection of the Body From External Risk Factors

The purpose of the research is to improve the indicators of the quality of predicting and diagnosing diseases caused by the action of external pathogenic factors through the use of indicators characterizing adaptation mechanisms to assess the level of body defense.

Methods. It is known that the body's defense system has a complex, hierarchically organized rather poorly studied structure of a non-stationary, dynamic type, which does not allow obtaining reliable models for a quantitative assessment of the body's defense level with subsequent selection of adequate preventive and therapeutic schemes. This work examines the issues of using indicators characterizing the adaptive mechanisms of the body for a quantitative assessment of the level of the body's defense against multiple exogenous factors. The methodology for the synthesis of hybrid fuzzy decision rules is used as a basic mathematical apparatus.

Results. The work shows that for a quantitative assessment of the level of protection of the body from external risk factors, indicators of adaptive potential, energy imbalance of BAP, adaptive compliance and a number of immunological indicators can be used. For these indicators, functions of the level of protection and a generalized indicator of the level of protection of the body in the form of a fuzzy decision rule were obtained. The mechanism of embedding this indicator into prognostic and diagnostic decision rules is shown. As a result of expert assessment and mathematical modeling, it was shown that the quality of decision-making using the proposed models increases by 10 -15%, depending on the type of problems being solved, in comparison with models that do not use indicators of the level of protection of the body.

Conclusion. In the course of the studies, it was shown that to improve the indicators of the quality of predicting and diagnosing diseases caused by the action of external pathogenic factors, indicators of the level of the body's defense determined by its adaptation mechanisms can be used. It was found that the quality of decision-making using the proposed models increases by 10 -15% depending on the type of tasks being solved in comparison with models that do not use indicators of the level of the body's defense

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