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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">uprinmatus</journal-id><journal-title-group><journal-title xml:lang="ru">Известия Юго-Западного государственного университета. Серия: Управление, вычислительная техника, информатика. Медицинское приборостроение</journal-title><trans-title-group xml:lang="en"><trans-title>Proceedings of the Southwest State University. Series: IT Management, Computer Science, Computer Engineering. Medical Equipment Engineering</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-1536</issn><publisher><publisher-name>Юго-Западный государственный университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21869/2223-1536-2025-15-4-192-210</article-id><article-id custom-type="elpub" pub-id-type="custom">uprinmatus-392</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МОДЕЛИРОВАНИЕ В МЕДИЦИНСКИХ И ТЕХНИЧЕСКИХ СИСТЕМАХ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MODELING IN MEDICAL AND TECHNICAL SYSTEMS</subject></subj-group></article-categories><title-group><article-title>Оценка эффективности модели глубокого обучения на основе EfficientNetB3 для дифференциальной диагностики стадий болезни Альцгеймера</article-title><trans-title-group xml:lang="en"><trans-title>Evaluation of the effectiveness of a deep learning model based on EfficientNetB3 for differential diagnosis of Alzheimer's disease stages</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7228-0281</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киселев</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiselev</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Киселев Алексей Викторович, кандидат технических наук, доцент, доцент кафедры вычислительной техники</p><p>ул. 50 лет Октября, д. 94, г. Курск 305040</p></bio><bio xml:lang="en"><p>Alexey V. Kiselev, Candidate of Sciences (Engineering), Associate Professor, Associate Professor of the Department of Computer Engineering</p><p>50 Let Oktyabrya Str. 94, Kursk 305040</p></bio><email xlink:type="simple">kiselevalexey1990@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8270-564X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулешова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuleshova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кулешова Елена Александровна, кандидат технических наук, доцент кафедры информационной безопасности</p><p>ул. 50 лет Октября, д. 94, г. Курск 305040</p></bio><bio xml:lang="en"><p>Elena A. Kuleshova, Candidate of Sciences (Engineering), Associate Professor, Associate Professor of the Department of Information Security</p><p>50 Let Oktyabrya Str. 94, Kursk 305040</p></bio><email xlink:type="simple">lena.kuleshova.94@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4099-1414</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Таныгин</surname><given-names>М. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Tanygin</surname><given-names>M. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Таныгин Максим Олегович, доктор технических наук, доцент, профессор кафедры информационной безопасности</p><p>ул. 50 лет Октября, д. 94, г. Курск 305040</p></bio><bio xml:lang="en"><p>Maxim O. Tanygin, Doctor of Sciences (Engineering), Associate Professor, Professor of the Department of Information Security</p><p>50 Let Oktyabrya Str. 94, Kursk 305040</p></bio><email xlink:type="simple">tanygin@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-2017-7107</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Свинухов</surname><given-names>П. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Svinuhov</surname><given-names>P. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Свинухов Павел Михайлович, аспирант кафедры информационной безопасности</p><p>ул. 50 лет Октября, д. 94, г. Курск 305040</p></bio><bio xml:lang="en"><p>Pavel R. Svinuhov, Postgraduate of the Department of Information Security</p><p>50 Let Oktyabrya Str. 94, Kursk 305040</p></bio><email xlink:type="simple">p.8848@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-1205-2139</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халин</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khalin</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Халин Игорь Алексеевич, аспирант кафедры биомедицинской инженерии</p><p>ул. 50 лет Октября, д. 94, г. Курск 305040</p></bio><bio xml:lang="en"><p>Igor A. Khalin, Postgraduate of the Department of Biomedical Engineeringи</p><p>50 Let Oktyabrya Str. 94, Kursk 305040</p></bio><email xlink:type="simple">yur-khalin@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Юго-Западный государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Southwest State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>28</day><month>01</month><year>2026</year></pub-date><volume>15</volume><issue>4</issue><fpage>192</fpage><lpage>210</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Киселев А.В., Кулешова Е.А., Таныгин М.О., Свинухов П.М., Халин И.А., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Киселев А.В., Кулешова Е.А., Таныгин М.О., Свинухов П.М., Халин И.А.</copyright-holder><copyright-holder xml:lang="en">Kiselev A.V., Kuleshova E.A., Tanygin M.O., Svinuhov P.M., Khalin I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://uprinmatus.elpub.ru/jour/article/view/392">https://uprinmatus.elpub.ru/jour/article/view/392</self-uri><abstract><p>Цель исследования – оценка эффективности применения модифицированной архитектуры EfficientNetB3 на основе методов трансферного глубокого обучения и ранней остановки в системах поддержки принятия врачебных решений для дифференциальной диагностики стадий болезни Альцгеймера.</p><sec><title>Методы</title><p>Методы. Для проведения экспериментальных исследований был сформирован набор данных для обучения, проведена нормализация и аугментация данных. Выполнена программная реализация модифицированной нейросетевой архитектуры EfficientNetB3 с применением методов трансферного глубокого обучения и ранней остановки на языке программирования Python. Проведено обучение нейросетевой модели.</p></sec><sec><title>Результаты</title><p>Результаты. Оценка эффективности классификации, обученной нейросетевой модели, проводилась с помощью метрик Recall, Precision, Specificity, F1-мера и AUC-ROC. Анализ значений этих метрик показал, что результаты, продемонстрированные модифицированной архитектурой EfficientNetB3, характеризуются выраженной асимметрией и указывают на узкоспециализированный характер данной модели. С одной стороны, модель проявила себя как эффективный инструмент для диагностики стадии умеренной деменции, продемонстрировав максимально возможное значение AUC. С другой стороны, эффективность классификации для остальных классов значительно ниже (значения AUC для классов «Отсутствие деменции», «Очень лёгкая деменция» и «Лёгкая деменция» равны 0,87, 0,86 и 0,95 соответственно).</p></sec><sec><title>Заключение</title><p>Заключение. Исходя из результатов проведенного анализа можно сделать вывод, что основная практическая ценность данной модификации архитектуры EfficientNetB3 заключается в ее использовании в составе гетерогенных ансамблей или каскадных системах диагностики для верификации конкретной стадии болезни Альцгеймера – умеренной деменции с целью повышения общей эффективности системы. Это указывает на перспективность дальнейших исследований в области создания узкоспециализированных архитектур, способных решать конкретные подзадачи с высокой точностью, превосходящей универсальные, но менее сфокусированные подходы.</p></sec></abstract><trans-abstract xml:lang="en"><p>The purpose of the research is evaluation of the effectiveness of the modified EfficientNetB3 architecture based on transfer deep learning and early stopping methods in medical decision support systems for differential diagnosis of Alzheimer's disease stages.</p><sec><title>Methods</title><p>Methods. To conduct experimental studies, a training dataset was generated, normalized, and augmented. A modified EfficientNetB3 neural network architecture was implemented using transfer learning and early stopping methods in Python. The neural network model was trained.</p></sec><sec><title>Results</title><p>Results. The classification performance of the trained neural network model was assessed using the Recall, Precision, Specificity, F1-score, and AUC-ROC metrics. Analysis of these metrics revealed that the results achieved by the modified EfficientNetB3 architecture are characterized by significant asymmetry, indicating the highly specialized nature of this model. On the one hand, the model proved to be an effective tool for diagnosing moderate dementia, demonstrating the highest possible AUC value. On the other hand, classification performance for the remaining classes was significantly lower (AUC values for the "No Dementia," "Very Mild Dementia," and "Mild Dementia" classes were 0,87, 0,86, and 0,95, respectively).</p></sec><sec><title>Conclusion</title><p>Conclusion. Based on the results of the analysis, it can be concluded that the primary practical value of this modification of the EfficientNetB3 architecture lies in its use in heterogeneous ensembles or cascaded diagnostic systems for verifying a specific stage of Alzheimer's disease – moderate dementia – in order to improve the overall system efficiency. This points to the potential for further research in the area of creating highly specialized architectures capable of solving specific subproblems with high accuracy, surpassing general-purpose but less focused approaches.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь Альцгеймера</kwd><kwd>нейросетевая модель</kwd><kwd>трансферное обучение</kwd><kwd>глубокое обучение</kwd><kwd>классификация</kwd><kwd>дифференциальная диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Alzheimer's disease</kwd><kwd>neural network model</kwd><kwd>transfer learning</kwd><kwd>deep learning</kwd><kwd>classification</kwd><kwd>differential diagnosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Особенности клинического течения нейродегенеративного заболевания головного мозга, обусловленного мутациями в гене нейрофасцита и сукцинатдегидрогеназы: клинический случай / Е. 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